Research evidences have showed that Chaihu Shugan San can increase the expression of 5-HT1A receptor, and thus promoting cell proliferation in dentate gyrus of hippocampus in epileptic rats with a depressive state, induced by pilocarpine and chronic mild stress (CMS), effectively improving some depressive symptoms [144]
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There are several ways those six cysteines can pair, only one of which is correct, and the incorrectly paired species have exactly the same molecular formula and exactly the same mass as the correct one
Madukwe et al., 2013)
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Slides were mounted with Fluoromount-G (Southern Biotech, USA) and examined using a Leica TCS SP5 AOBS confocal laser scanning microscope (Leica Microsystems, Germany) equipped with HCX PL APO 63 oil (NA = 1.4) objectives